Weidong Liu, Yiwu Zheng, Xudong Kong, Christian Heinis, Yibing Zhao, and Chuanliu Wu*, Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One-Pot Reaction, Angew. Chem. Int. Ed., 2017, 56, 4458−4463 (Hot paper, featured as inside back cover).
Disulfide-rich peptides are emerging as potential templates for drug design applications However, the synthesis and reengineering of disulfide-rich peptides is challenging, owing to the complexity of the oxidative folding process involving a number of diRead More →
Peptides have been a promising molecular scaffold for the development of potential therapeutics with high affinity and specificity to biomacromolecules However, their inherent proteolytic instability significantly hampers their biological applicationsRead More →
In this work, we report the discovery of a small phenyl molecule with four isosteric thiolate-reactive groups of sequentially-varied reactivity, and how this molecule was exploited in combination with cysteine penicillamine thiolates of differentRead More →