2024
Zengping Duan‡, Chuilian Kong‡, Shihui Fan, and Chuanliu Wu*, Triscysteine disulfide-directing motifs enabling design and discovery of multicyclic peptide binders, Nat. Commun., 2024, 15, 7799.
Lulu Song‡, Hongtan Liu‡, Maolin Li, Yawen Yang, Huilei Dong, Jinjing Li, Jiaqi Shao, Lixu Zhi, Hao Sun, Zhifeng Li, Haiyan Sui, Youming Zhang, Chuanliu Wu*, and Yizhen Yin*, Ribosomal Incorporation of Lithocholic Acid into Peptides for the De Novo Discovery Of Peptide-Lithocholic Acid Hybrid Macrocyclic Peptides, ACS Chem. Bio., 2024, 19, 1440–1446.
Fengwei Li‡, Junjie Liu‡, Chao Liu‡, Ziyan Liu, Xiangda Peng, Yinyue Huang, Xiaoyu Chen, Xiangnan Sun, Sen Wang, Wei Chen, Dan Xiong, Xiaotong Diao, Sheng Wang, Jingjing Zhuang, Chuanliu Wu*, and Dalei Wu*, Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy
, Nat. Commun., 2024, 15, 1476.
Alexander J. Lander, Yifu Kong, Yi Jin*, Chuanliu Wu*, and Louis Y. P. Luk*, Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and d-Peptide Ligand Discovery, ACS Bio Med Chem Au, 2024, 1, 68–76.
2023
Jinjing Li‡, Hongtan Liu‡, Shuling Xiao, Shihui Fan, Xueting Cheng, and Chuanliu Wu*, De Novo Discovery of Cysteine Frameworks for Developing Multicyclic Peptide Libraries for Ligand Discovery, J. Am. Chem. Soc., 2023, 145, 28264–28275.
Xiaoting Meng‡, Chaoying Xu‡, Shihui Fan, Meng Dong, Jie Zhuang, Zengping Duan, Yibing Zhao, and Chuanliu Wu*, Selection and evolution of disulfide-rich peptides via cellular protein quality control, Chem. Sci., 2023, 14, 3668–3675.
Shuaimin Lu‡, Shihui Fan‡, Shuling Xiao, Jinjing Li, Shilong Zhang, Yapei Wu, Chuilian Kong, Jie Zhuang, Hongtan Liu, Yibing Zhao, and Chuanliu Wu*, Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs, J. Am. Chem. Soc., 2023, 145, 1964–1972.
2022
Yapei Wu‡, Shihui Fan‡, Meng Dong, Jinjing Li, Chuilian Kong, Jie Zhuang, Xiaoting Meng, Shuaimin Lu, Yibing Zhaoa and Chuanliu Wu*, Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery, Chem. Sci., 2022, 13, 7780-7789.
Sicong Yao‡, Adam Moyer‡, Yiwu Zheng‡, Yang Shen, Xiaoting Meng, Chong Yuan, Yibing Zhao, Hongwei Yao*, David Baker* & Chuanliu Wu*, De novo design and directed folding of disulfide-bridged peptide heterodimers, Nat. Comm., 2022, 13, 1539.
Huilei Dong‡, Jinjing Li‡, Hongtan Liu, Shuaimin Lu, Junjie Wu, Youming Zhang, Yizhen Yin*, Yibing Zhao, and Chuanliu Wu*, Design and Ribosomal Incorporation of Noncanonical Disulfide-Directing Motifs for the Development of Multicyclic Peptide Libraries, J. Am. Chem. Soc., 2022, 144, 5116–5125.
2021
Yaqi Wu‡, Cong Li‡, Shihui Fan, Yibing Zhao*, and Chuanliu Wu*, Fast and Selective Reaction of 2-Benzylacrylaldehyde with 1,2-Aminothiol for Stable N-Terminal Cysteine Modification and Peptide Cyclization, Bioconjugate Chem., 2021, 32, 2065–2072.
Jun Zha, Jinjing Li, Shihui Fan, Zengping Duan, Yibing Zhao* and Chuanliu Wu*, An evolution-inspired strategy to design disulfide-rich peptides tolerant to extensive sequence manipulation, Chem. Sci., 2021, 12, 11464–11472.
2020
Shuaimin Lu‡, Yapei Wu‡, Jinjing Li, Xiaoting Meng, Chenliang Hu, Yibing Zhao, and Chuanliu Wu*, Directed Disulfide Pairing and Folding of Peptides for the De Novo Development of Multicyclic Peptide Libraries, J. Am. Chem. Soc., 2020, 142, 16285–16291.
Xuejun Zheng, Weidong Liu, Ziyan Liu, Yibing Zhao, Chuanliu Wu*, Biocompatible and Rapid Cyclization of Peptides with 2,4-Difluoro-6-hydroxy-1,3,5-benzenetricarbonitrile for the Development of Cyclic Peptide Libraries, Bioconjugate Chem., 2020, 31, 2085–2091.
Zirong Huang, Yapei Wu, Huilei Dong, Yibing Zhao, and Chuanliu Wu*, Design and Synthesis of Disulfide-Rich Peptides with Orthogonal Disulfide Pairing Motifs, J. Org. Chem., 2020, 85, 11475–11481.
Xiaoli Zheng, Zhuoru Li, Wei Gao, Xiaoting Meng, Xuefei Li, Louis Y. P. Luk, Yibing Zhao, Yu-Hsuan Tsai*, Chuanliu Wu*, Condensation of 2-((Alkylthio)(aryl)methylene)malononitrile with 1,2-Aminothiol as a Novel Bioorthogonal Reaction for Site-Specific Protein Modification and Peptide Cyclization, J. Am. Chem. Soc., 2020, 142, 5097-5103.
2019
Jun Liu‡, Jiingjing Liang‡, Chuanliu Wu*, and Yibing Zhao*, A Doubly-Quenched Fluorescent Probe for Low-Background Detection of Mitochondrial H2O2, Anal. Chem., 2019, 91, 6902−6909.
Yiwu zheng, Yang Shen, Xiaoting Meng, Yaqi Wu, Yibing Zhao*, and Chuanliu Wu*,Stabilizing p-dithiobenzyl Urethane Linkers without Rate-Limiting Self-Immolation for Traceless Drug Release, ChemMedChem, 2019, 14, 1196–1203
Huilei Dong, Xiaoting Meng, Xiaoli Zheng, Xueting Cheng, Yiwu Zheng, Yibing Zhao, Chuanliu Wu*, Design and Synthesis of Crosslink-Dense Peptides by Manipulating Regioselective Bisthioether Crosslinking and Orthogonal Disulfide Pairing, J. Org. Chem., 2019, 84, 5187−5194.
Yaqi Chen‡, Jingjing Liang‡, Tao Li, Ping Lin, Yibing Zhao, Chuanliu Wu*, Interchain Doubly-Bridged α-Helical Peptides for the Development of Protein Binders, Chin. Chem. Lett., 2019, 30, 924−928.
Ping Lin‡, Hongwei Yao‡, Jun Zha, Yibing Zhao, Chuanliu Wu*, Ordered and Isomerically‐Stable Bicyclic Peptide Scaffolds Constrained through Cystine Bridges and Proline Turns. ChemBioChem. 2019, 20, 1514–1518.
Yizhen Yin‡, Qianran Fei‡, Weidong Liu, Zhuoru Li, Hiroaki Suga*, Chuanliu Wu*, Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation, Angew. Chem. Int. Ed., 2019, 58, 4880–4885.
2018
Xiaoting Meng, Tao Li, Yibing Zhao, Chuanliu Wu*, CXC-Mediated Cellular Uptake of Miniproteins: Forsaking "Arginine Magic", ACS Chem. Biol., 2018, 11, 3078–3086.
Mirao Zha, Ping Lin, Hongwei Yao, Yibing Zhao, Chuanliu Wu*,A Phage Display-Based Strategy for the De Novo Creation of Disulfide-Constrained and Isomer-Free Bicyclic Peptide Affinity Reagents, Chem. Commun., 2018, 54, 4029–4032.
Yiwu Zheng, Xiaoting Meng, Yaqi Wu, Yibing Zhao, and Chuanliu Wu*, De Novo Design of Constrained and Sequence-Independent Peptide Scaffolds with Topologically-Formidable Disulfide Connectivities, Chem. Sci., 2018, 9, 569–575.
Weidong Liu and Chuanliu Wu*, A Mini-Review and Perspective on Multicyclic Peptide Mimics of Antibodies, Chin. Chem. Lett., 2018, 29, 1063–1066.
Chaoyu Li‡, Jinhong Gao‡, Jun Yi‡, Xiaguang Zhang, Xiaodan Cao, Meng Meng, Chen Wang, Yaping Huang, Sanjun Zhang, Deyin Wu, Chuanliu Wu*, Jianhua Xu, Zhongqun Tian, and Jianfeng Li*, Plasmon-Enhanced Ultrasensitive Surface Analysis Using Ag Nanoantenna, Anal. Chem., 2018, 90, 2018−2022.
2017
Weidong Liu, Yiwu Zheng, Xudong Kong, Christian Heinis, Yibing Zhao, and Chuanliu Wu*, Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One-Pot Reaction, Angew. Chem. Int. Ed., 2017, 56, 4458−4463 (Hot paper, featured as inside back cover).
Yiwu Zheng, Zhuoru Li, Jing Ren, Weidong Liu, Yaqi Wu, Yibing Zhao, and Chuanliu Wu*, Artificial Disulfide-Rich Peptide Scaffolds with Precisely Defined Disulfide Patterns and a Minimized Number of Isomers, Chem. Sci., 2017, 8, 2547−2552 (Featured as inside front cover).
Yiwu Zheng, Jing Ren, Yaqi Wu, Xiaoting Meng, Yibing Zhao, and Chuanliu Wu*, Proteolytic Unlocking of Ultrastable Twin-Acylhydrazone Linkers for Lysosomal Acid-Triggered Release of Anticancer Drugs , Bioconjugate. Chem., 2017, 28, 2620−2626.
Jinghui Wang, Mirao Zha, Qianran Fei, Weidong Liu, Yibing Zhao, and Chuanliu Wu*, Peptide Macrocycles Developed from Precisely-Regulated Multiple Cyclization of Unprotected Peptides , Chem. Eur. J., 2017, 23, 15150−15155.
Tao Li, Wei Gao, Jingjing Liang, Mirao Zha, Yaqi Chen, Yibing Zhao, and Chuanliu Wu*, Biscysteine-Bearing Peptide Probes to Reveal Extracellular Thiol-Disulfide Exchange Reactions Promoting Cellular Uptake , Anal. Chem., 2017, 89, 8501−8508.
Wei Gao‡, Tao Li‡, Jinghui Wang, Yibing Zhao, and Chuanliu Wu*, Thioether-Bonded Fluorescent Probes for Deciphering Thiol-Mediated Exchange Reactions on the Cell Surface, Anal. Chem., 2017, 89, 937−944.
Jun Liu, Shunqing Zhou, Jing Ren, Chuanliu Wu*, and Yibing Zhao*, A Lysosome-Locating and Acidic pH-Activatable Fluorescent Probe for Visualizing Endogenous H2O2 in Lysosomes, Analyst, 2017, 142, 4522−4528.
Jinhong Gao, Zhuoru Li, Ouyang Zhang, Chuanliu Wu*, and Yibing Zhao*,
Tunable Accessibility of Dye-doped Liposomes towards Gold Nanoparticles for Fluorescent Sensing of Lipopolysaccharide
, Analyst, 2017, 142, 1084−1090.
Yaqi Chen‡, Tao Li‡, Jianguo Li, Shiyan Cheng, Jinghui Wang, Chandra Verma, Yibing Zhao, and Chuanliu Wu*, Stabilization of Peptides against Proteolysis through Disulfide-Bridged Conjugation with Synthetic Aromatics, Org. Biomol. Chem., 2017, 15,1921−1929.
2016
Yunyang Ling‡, Jing Ren‡, Tao Li, Yibing Zhao, and Chuanliu Wu*, POEGMA-Based Disulfide-Containing Fluorescent Probes for Imitating and Tracing Noninternalization-Based Intracellular Drug Delivery, Chem. Commun., 2016, 52,4533−4536.
Jingjing Liang, Tao Li, Xiaojia Bao, Jing Ren, Yibing Zhao, and Chuanliu Wu*, Disulfide-Linked/Peptide-Incorporated Macrocycles Unique Redox-Responsiveness and Application for Intracellular Cargo-Delivery, ChemistrySelect, 2016, 4, 826−830.
Jun Liu, Jing Ren, Xiaojia Bao, Wei Gao, Chuanliu Wu*, and Yibing Zhao*, pH-Switchable Fluorescent Probe for Spatially-Confined Visualization of Intracellular Hydrogen Peroxide, Anal. Chem., 2016, 88, 5865−5870.
Jinhong Gao, Ouyang Zhang, Jing Ren, Chuanliu Wu*, and Yibing Zhao*, Aromaticity/Bulkiness of Surface Ligands to Promote the Interaction of Anionic Amphiphilic Gold Nanoparticles with Lipid Bilayers, Langmuir, 2016, 32, 1601−1610.
Shuo Liu‡, Jianbin Chen‡,Xiaojia Bao, Tao Li, Yunyang Ling, Chunxiang Li, Yibing Zhao, and Chuanliu Wu*, Metal-Organic-Framework-Templated Polyelectrolyte Nanocapsules for the Encapsulation and Delivery of Small-Molecule-Polymer Conjugates, Chem. Commun., 2016, 11,1811−1820.
2015
Yiwu Zheng, Linxiang Zhai, Yibing Zhao, and Chuanliu Wu*, Orthogonal Cysteine-Penicillamine Disulfide Pairing for Directing the Oxidative Folding of Peptides, J. Am. Chem. Soc., 2015, 137, 15094−15097.
Yujie Li‡, Tao Li‡, Jinghui Wang, Xiaojia Bao, Yibing Zhao, and Chuanliu Wu*, Multivalent Peptides Displayed on OEGMA-based Copolymers for the Modulation of Protein-Protein Interactions, Polym. Chem., 2015, 6, 7862−7870.
Yaqi Chen‡, Chaoqiong Yang‡, Tao Li, Miao Zhang, Yang Liu, Marc A. Gauthier, Yibing Zhao, and Chuanliu Wu*, The Interplay of Disulfide Bonds, α-Helicity, and Hydrophobic Interactions Leads to Ultrahigh Proteolytic Stability of Peptides, Biomacromolecules, 2015,16, 2347−2355.
Rongkun He, Ming Hu, Ting Xu, Chunxiang Li, Chuanliu Wu*, Xiangqun Guo*, and Yibing Zhao*, Conjugated Copolymer-Photosensitizer Molecular Hybrids with Broadband Visible Light Absorption for Efficient Light-Harvesting and Enhanced Singlet Oxygen Generation, J. Mater. Chem. C, 2015, 3, 973−976.
2014
Linxiang Zhai, Jingjing Liang, Xiangqun Guo, Yibing Zhao, and Chuanliu Wu*, Extraordinary Modulation of Disulfide Redox-Responsiveness by Cooperativity of Twin-Disulfide Bonds, Chem. Eur. J., 2014, 20, 17507−17514.
Shuo Liu, Linxiang Zhai, Chunxiang Li, Yujie Li, Xiangqun Guo, Yibing Zhao, and Chuanliu Wu*, Exploring and Exploiting Dynamic Noncovalent Chemistry for Effective Surface Modification of Nanoscale Metal-Organic Frameworks, ACS Appl. Mater. Interfaces, 2014, 6, 5404−5412.
Chong Li, Yujie Li, Yunyang Ling, Yangwei Lai, Chuanliu Wu*, and Yibing Zhao*, Exploration of the Growth Process of Ultrathin Silica Shells on the Surface of Gold Nanorods by the Localized Surface Plasmon Resonance, Nanotechnology, 2014, 25, 045704 (7pp).
2013
Jinhong Gao, Yangwei Lai, Chuanliu Wu,* and Yibing Zhao*, Exploring and Exploiting the Synergy of Non-Covalent Interactions on the Surface of Gold Nanoparticles for Fluorescent Turn-On Sensing of Bacterial Lipopolysaccharide, Nanoscale, 2013, 5, 8242–8248.
Chuanliu Wu, Shuo Wang, Lorine Brülisauer, Jean-Christophe Leroux, and Marc A. Gauthier*,
Broad Control of Disulfide Stability through Microenvironmental Effects and Analysis in Complex Redox Environments
, Biomacromolecules, 2013, 14, 2383−2388.
2007-2012
Chuanliu Wu, Jean-Christophe Leroux,* and Marc A. Gauthier*, Twin Disulfides for Orthogonal Disulfide Pairing and the Directed Folding of Multicyclic Peptides, Nature Chem., 2012, 4, 1044−1049.
Chuanliu Wu, Cristina Belenda, Jean-Christophe Leroux, and Marc A. Gauthier*, Interplay of Chemical Microenvironment and Redox Environment on Thiol–Disulfide Exchange Kinetics,Chem. Eur. J., 2011, 17, 10064−10070.
Chuanliu Wu and Qing-Hua Xu*, Stable and Functionable Mesoporous Silica-Coated Gold Nanorods as Sensitive Localized Surface Plasmon Resonance (LSPR) Nanosensors, Langmuir, 2009, 25, 9441−9446.
Chuanliu Wu and Qing-Hua Xu*, Enhanced One- and Two-Photon Excitation Emission of a Porphyrin Photosensitizer by FRET from a Conjugated Polyelectrolyte, Macromolecular Rapid Communications, 2009, 30, 504−508.
Chuanliu Wu, Jinqing Hong, Xiangqun Guo, Chaobiao Huang, Jinping Lai, Jinsheng Zheng, Jianbin Chen, Xue Mu, and Yibing Zhao*, Fluorescent Core-Shell Silica Nanoparticles as Tunable Precursors: towards Encoding and
Multifunctional Nano-probes, Chem. Commun., 2008, 750−752.
Multifunctional Nano-probes, Chem. Commun., 2008, 750−752.
Chuanliu Wu, Chen Chen, Jinping Lai, Jianbin Chen, Xue Mu, Jinsheng Zheng, and Zhao, Yibing*, Molecule-Scale Controlled-Release System based on Light-Responsive Silica Nanoparticles, Chem. Commun., 2008, 2662−2664.
Chuanliu Wu, Jinsheng Zheng, Chaobiao Huang, Jinping Lai, Shuyan Li, Chen Chen, and Yibing Zhao*, Hybrid Silica-Nanocrystal-Organic Dye Superstructures as Post-Encoding Fluorescent Probes, Angew. Chem. Int. Ed., 2007, 46, 5393−5396.
Chuanliu Wu and Yibing Zhao*, CdS Quantum Dots as Fluorescence Probes for the Sensitive and Selective Detection of Highly Reactive HSe- Ions in Aqueous Solution，Anal. Bioanal. Chem., 2007, 388, 717−722.