Peptide Ligands and Drugs
23 Oct 19
We are developing structurally-constrained peptide ligands for proteins of potential therapeutic interest. Our interests include: 1) cyclization strategies for peptides, 2) strategies for intracellula...
Oxidative Folding of Polypeptides
23 Oct 19
The precise pairing of cysteine (Cys) residues is essential for the conformational folding and stabilization of many proteins and natural disulfide-rich peptides. In natural systems, precise disulfide...
Fluorescent Probes
23 Oct 19
Novel fluorescent probes that are developing in our lab include: 1) FRET-based probes for deciphering thiol-mediated (thiol-disulfide) exchange reactions on the cell surface or in the endocytic pathwa...